Physico-Chemical & Residue Studies
Solubility
Determines aqueous and organic solvent solubility using validated methods, applying temperature-controlled and pH-dependent protocols where required. Our analytical team has experience with challenging low-solubility compounds, including highly lipophilic and ionizable substances. Study results are documented with full method validation evidence and analytical traceability.
Stability
Conducts stability studies including accelerated, intermediate, and long-term storage condition testing, as well as hydrolytic, photolytic, and thermal stability evaluations. Our analytical chemistry team applies validated stability-indicating methods to quantify parent compound and degradants at each time point, with appropriate mass balance confirmation.
Partition Coefficient
Determines log Pow using the shake flask (OECD TG 107) and HPLC estimation (OECD TG 117) methods, with method selection guided by the physicochemical characteristics of the test substance. Our analytical team applies rigorous purity confirmation and pH control to minimize variability, particularly for ionizable substances.
Residue Analysis (Plant & Environmental Matrices)
Applies validated, fit-for-purpose analytical methods covering extraction, cleanup, and quantification by LC-MS/MS and GC-MS/MS platforms. Our residue chemistry team has experience across a broad range of commodity types and matrices, including high-moisture, high-fat, and soil-bound residue scenarios.
Analytical Method Validation (Routine & Regulatory)
Conducts routine and full regulatory validation studies covering the complete validation parameter set, including linearity, accuracy, precision, LOD, LOQ, specificity, and stability. Our analytical team has validated methods for a wide range of matrices — including biological fluids, plant commodities, soil, water, and environmental sediments — and has experience resolving interference and matrix effect challenges.
Metabolite Profiling (Basic)
Conducts basic metabolite profiling studies using LC-HRMS and MS/MS fragmentation approaches, supported by NMR characterization where structural confirmation is required. Our scientists have experience identifying and characterizing metabolites present at trace levels in complex biological matrices, applying chromatographic fractionation and enrichment strategies when standard approaches do not provide adequate sensitivity: