Discovery, Biology & Early Pharmacology
In-vitro Pharmacology & Screening Assays
Vanta’s assay development team has over a decade of experience designing and executing primary and counter-screening panels across diverse target classes. Our robust quality systems and documented assay validation support confident go/no-go decisions at the earliest stages of development.
Cell-Based Functional Assays
Vanta Bioscience operates with well-characterized cell lines and primary cell systems, applying rigorous assay qualification to ensure data reliability across experimental runs. Our experience spans small molecules, biologics, and combination products, allowing sponsors to obtain actionable functional data aligned with early regulatory expectations.
Mechanism of Action (MoA) Studies
Our scientific team works closely with sponsors to design purpose-built MoA packages that address specific regulatory queries or unresolved pharmacological questions. This structured approach minimizes data gaps that commonly delay IND submissions or create uncertainty during regulatory review.
Disease-Relevant Cellular Models
Established experience working with complex cellular systems and applying appropriate endpoint panels, including cytotoxicity, proliferation, differentiation, and gene expression markers. We help sponsors generate data that strengthens translational rationale and regulatory confidence.
Early In-vivo Efficacy Models
In-vivo team has conducted efficacy studies across a broad range of disease areas — including inflammation, metabolic disorders, oncology, and infection — with extensive experience in rodent and non-rodent models. Our integrated study designs simultaneously capture preliminary PK/PD data, improving efficiency and reducing the total number of animals required.
Pharmacokinetics (PK)
Vanta conducts single- and multiple-dose PK studies across standard laboratory species, employing validated bioanalytical methods to ensure data accuracy and traceability. Our PK scientists have extensive experience interpreting non-linear kinetics, food-effect variability, and route-dependent absorption profiles. Resulting datasets are formatted and documented to directly support IND regulatory packages.
Toxicokinetics (TK)
Vanta integrates TK assessments into repeat-dose and acute toxicity studies, applying ICH S3A-aligned sampling strategies and validated bioanalytical methods. Our experience with diverse molecule classes — including poorly soluble compounds, high-protein-binding molecules, and metabolically labile candidates — ensures that TK data reliably reflects true in-vivo exposure.